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Tumor budding to investigate local invasion, metastasis, and prognosis of head and neck carcinoma: A systematic review.
Zanoletti, Elisabetta; Daloiso, Antonio; Nicolè, Lorenzo; Cazzador, Diego; Mondello, Tiziana; Franz, Leonardo; Astolfi, Laura; Marioni, Gino.
Afiliação
  • Zanoletti E; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, Padova, Italy.
  • Daloiso A; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, Padova, Italy.
  • Nicolè L; Department of Medicine (DIMED), University of Padova, Padova, Italy.
  • Cazzador D; Pathology & Cytopathology Unit, Ospedale dell'Angelo, Venezia-Mestre, Italy.
  • Mondello T; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, Padova, Italy.
  • Franz L; Otolaryngology Section, Department of Neuroscience DNS, University of Padova, Padova, Italy.
  • Astolfi L; Phoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, Treviso, Italy.
  • Marioni G; Bioacoustics Research Laboratory, Department of Neuroscience DNS, University of Padova, Padova, Italy.
Head Neck ; 46(3): 651-671, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38013617
The aim of this systematic review is to shed light on the role of tumor budding (TB) in the biology, behavior, and prognosis of head and neck squamous cell carcinoma (HNSCC). A search was run in PubMed, Scopus, and Embase databases following PRISMA guidelines. After full-text screening and application of inclusion/exclusion criteria, 36 articles were included. Several investigations support the prognostic role of TB, which might play a role in selecting rational treatment strategies. To achieve this goal, further research is needed for greater standardization in TB quantification. Although TB is not included as a negative prognostic factor in the current management guidelines, it might be reasonable to consider a closer follow-up for HNSCC cases with high histopathological evidence of TB.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2024 Tipo de documento: Article