mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory.
Proc Natl Acad Sci U S A
; 120(49): e2308671120, 2023 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-38015848
ABSTRACT
Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learning in the contextual fear conditioning paradigm engenders a decrease in eIF2α (eukaryotic translation initiation factor 2) phosphorylation in astrocytes in the hippocampal CA1 region, which promotes protein synthesis. Genetic reduction of eIF2α phosphorylation in hippocampal astrocytes enhanced contextual and spatial memory and lowered the threshold for the induction of long-lasting plasticity by modulating synaptic transmission. Thus, learning-induced dephosphorylation of eIF2α in astrocytes bolsters hippocampal synaptic plasticity and consolidation of long-term memories.
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MEDLINE
Assunto principal:
Astrócitos
/
Potenciação de Longa Duração
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article