Review on chronic metabolic diseases surrounding bile acids and gut microbiota: What we have explored so far.
Life Sci
; 336: 122304, 2024 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-38016578
ABSTRACT
Bile acid, the final product of cholesterol breakdown, functions as a complex regulator and signaling factor in human metabolism. Chronic metabolic diseases pose significant medical challenges. Growing research underscores bile acids' capacity to enhance metabolism via diverse pathways, regulating disorders and offering treatment potential. Numerous bile-acid-triggered pathways have become treatment targets. This review outlines bile acid synthesis, its role as a signal in chronic metabolic diseases, and highlights its interaction with gut microbiota in different metabolic conditions. Exploring host-bacteria-bile acid links emerges as a valuable future research direction with clinical implications.
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Base de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
/
Doenças Metabólicas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article