Novel pyrazolothienopyridinones as potential GABA<sub>A</sub> receptor modulators.

Vega Alanis, Blanca Angelica; Wimmer, Laurin; Ernst, Margot; Schnürch, Michael; Mihovilovic, Marko D

Novel pyrazolothienopyridinones as potential GABA_A receptor modulators.

Vega Alanis, Blanca Angelica; Wimmer, Laurin; Ernst, Margot; Schnürch, Michael; Mihovilovic, Marko D.

Afiliação

Vega Alanis BA; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.
Wimmer L; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.
Ernst M; Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
Schnürch M; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.
Mihovilovic MD; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.

Monatsh Chem ; 154(12): 1427-1439, 2023.

Article em En | MEDLINE | ID: mdl-38020488

ABSTRACT

ABSTRACT

The synthesis of novel pyrazolothienopyridinone derivatives as potential GABAA receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds. Supplementary Information The online version contains supplementary material available at 10.1007/s00706-023-03063-6.

Palavras-chave

Drug research; Electron-rich heterocyclic amines; GABAA Receptor Modulators; Heterocycles; Scaffold Hopping

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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