SRSF1 inhibits ferroptosis and reduces cisplatin chemosensitivity of triple-negative breast cancer cells through the circSEPT9/GCH1 axis.

Song, Xiang; Wang, Xinzhao; Chen, Xiqi; Yu, Zhiyong; Zhou, Yongkun

Song, Xiang; Wang, Xinzhao; Chen, Xiqi; Yu, Zhiyong; Zhou, Yongkun.

Afiliação

Song X; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China; Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.
Wang X; Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; REMEGEN, LTD, Yantai Economic & Technological Development Area, Yantai, Shandong 264006, China.
Chen X; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China; Department of General Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China.
Yu Z; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China; Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.
Zhou Y; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China; Department of General Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China. Electronic address: zhouyongkunn@163.com.

J Proteomics ; 292: 105055, 2024 02 10.

Article em En | MEDLINE | ID: mdl-38040194

Assuntos

Antineoplásicos; Ferroptose; Neoplasias de Mama Triplo Negativas; Humanos; Cisplatino/farmacologia; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Antineoplásicos/farmacologia; RNA Circular/farmacologia; GTP Cicloidrolase/farmacologia; Espécies Reativas de Oxigênio; Resistencia a Medicamentos Antineoplásicos/genética; Linhagem Celular Tumoral; Fatores de Processamento de RNA; Proliferação de Células; Fatores de Processamento de Serina-Arginina

Palavras-chave

Cisplatin; Ferroptosis; SRSF1; Triple negative breast cancer; circSEPT9

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Ferroptose / Antineoplásicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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