Design, development and bio-evaluation of a novel radio-ligand <sup>99m</sup>Tc-THQ-DTPA as a sigma 2 receptor specific breast tumor imaging agent.

Chaudhary, Vishakha; Chaturvedi, Shubhra; Wadhwa, Anju; Chaudhary, Ritika; Gautam, Divya; Sharma, Deepika; Kumar, Rupesh; Mishra, A K

Design, development and bio-evaluation of a novel radio-ligand ^99mTc-THQ-DTPA as a sigma 2 receptor specific breast tumor imaging agent.

Chaudhary, Vishakha; Chaturvedi, Shubhra; Wadhwa, Anju; Chaudhary, Ritika; Gautam, Divya; Sharma, Deepika; Kumar, Rupesh; Mishra, A K.

Afiliação

Chaudhary V; Kirori Mal College, University of Delhi, North Campus, University Enclave, Delhi 110007, India; Department of Radiological Nuclear and Imaging Science, INMAS, DRDO, Timarpur, Delhi 110054, India.
Chaturvedi S; Department of Radiological Nuclear and Imaging Science, INMAS, DRDO, Timarpur, Delhi 110054, India. Electronic address: Shubhra.inmas@gov.in.
Wadhwa A; University of California, San Francisco 94107, United States.
Chaudhary R; Department of Radiological Nuclear and Imaging Science, INMAS, DRDO, Timarpur, Delhi 110054, India; Dr. B.R. Ambedkar Center for Biomedical Research, University Enclave, Delhi 110007, India.
Gautam D; Department of Radiological Nuclear and Imaging Science, INMAS, DRDO, Timarpur, Delhi 110054, India; Centre for Nanotechnology, Indian Institute of Technology, Roorkee 247667, India.
Sharma D; Department of Radiological Nuclear and Imaging Science, INMAS, DRDO, Timarpur, Delhi 110054, India; Department of Chemistry, Banaras Hindu University, Varanasi 221005, India.
Kumar R; Kirori Mal College, University of Delhi, North Campus, University Enclave, Delhi 110007, India.
Mishra AK; Department of Radiological Nuclear and Imaging Science, INMAS, DRDO, Timarpur, Delhi 110054, India. Electronic address: akmishra63@gmail.com.

Bioorg Med Chem ; 97: 117515, 2024 01 01.

Article em En | MEDLINE | ID: mdl-38043245

Assuntos

Receptores sigma; Neoplasias de Mama Triplo Negativas; Ratos; Camundongos; Humanos; Animais; Ligantes; Neoplasias de Mama Triplo Negativas/diagnóstico por imagem; Camundongos Nus; Ácido Pentético; Receptores sigma/metabolismo; Compostos Radiofarmacêuticos; Linhagem Celular Tumoral; Tomografia Computadorizada de Emissão de Fóton Único

Palavras-chave

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; SPECT Imaging; Sigma-2 receptor; Triple negative breast cancer (TNBC); Tumor imaging

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores sigma / Neoplasias de Mama Triplo Negativas Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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