Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy.

Song, Qixiang; Ma, Heng; Zhu, Lili; Qi, Zehong; Lan, Zijun; Liu, Ke; Zhang, Huali; Wang, KangKai; Wang, Nian

Song, Qixiang; Ma, Heng; Zhu, Lili; Qi, Zehong; Lan, Zijun; Liu, Ke; Zhang, Huali; Wang, KangKai; Wang, Nian.

Afiliação

Song Q; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Ma H; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Zhu L; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Qi Z; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Lan Z; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Liu K; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Zhang H; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China.
Wang K; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China. Electronic address: wangkangkai@csu.edu.cn
Wang N; Department of Pathophysiology, School of Basic Medical Science, Central South University, 110 Xiangya Road, Changsha 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, 110 Xiangya Road, Changsha 410083, China. Electronic address: wangnian@csu.edu.cn.

Int Immunopharmacol ; 126: 111315, 2024 Jan 05.

Article em En | MEDLINE | ID: mdl-38043267

Assuntos

Endotoxemia; Cardiopatias; Animais; Camundongos; Ratos; Cardiopatias/metabolismo; Lipopolissacarídeos/farmacologia; Mitofagia; Miócitos Cardíacos/metabolismo; Monoéster Fosfórico Hidrolases/metabolismo; Monoéster Fosfórico Hidrolases/farmacologia; Proteínas Quinases/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Regulação para Cima

Palavras-chave

Cardiac Dysfunction; Endotoxemia; Mitophagy; PTPN1; STAT3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotoxemia / Cardiopatias Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotoxemia / Cardiopatias Idioma: En Ano de publicação: 2024 Tipo de documento: Article