Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa.
J Clin Invest
; 134(3)2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-38051587
ABSTRACT
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate single-cell RNA sequencing, spatial transcriptomics, and immunostaining to provide an unprecedented view of the pathogenesis of chronic HS, characterizing the main cellular players and defining their interactions. We found a striking layering of the chronic HS infiltrate and identified the contribution of 2 fibroblast subtypes (SFRP4+ and CXCL13+) in orchestrating this compartmentalized immune response. We further demonstrated the central role of the Hippo pathway in promoting extensive fibrosis in HS and provided preclinical evidence that the profibrotic fibroblast response in HS can be modulated through inhibition of this pathway. These data provide insights into key aspects of HS pathogenesis with broad therapeutic implications.
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Base de dados:
MEDLINE
Assunto principal:
Hidradenite Supurativa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article