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In Situ Stability Test for mRNA Vaccines Based on Deep-UV Resonance Raman Spectroscopy.
Almehmadi, Lamyaa M; Reverdatto, Sergei V; Ermolenkov, Vladimir V; Shekhtman, Alexander; Lednev, Igor K.
Afiliação
  • Almehmadi LM; Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, United States.
  • Reverdatto SV; The RNA Institute, College of Arts and Science, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, United States.
  • Ermolenkov VV; Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, United States.
  • Shekhtman A; The RNA Institute, College of Arts and Science, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, United States.
  • Lednev IK; The RNA Institute, College of Arts and Science, University at Albany, SUNY, 1400 Washington Avenue, Albany, New York 12222, United States.
Anal Chem ; 96(3): 1003-1008, 2024 01 23.
Article em En | MEDLINE | ID: mdl-38052070
ABSTRACT
Deep-UV resonance Raman spectroscopy has been shown to offer great potential for probing the in situ stability of mRNA vaccines. In this study, a vaccine model was subjected to controlled degradation using RNase A or through aging at room temperature. The degradation of mRNA was confirmed by using a cell transfection test and by gel electrophoresis. Under both settings, DUVRR spectroscopy successfully revealed the mRNA degradation signs of the vaccine model.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise Espectral Raman / Vacinas de mRNA Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise Espectral Raman / Vacinas de mRNA Idioma: En Ano de publicação: 2024 Tipo de documento: Article