Transmembrane protein 14A protects glomerular filtration barrier integrity.
Physiol Rep
; 11(23): e15847, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38054547
ABSTRACT
Transmembrane protein 14A (TMEM14A) is a relatively unknown protein that is now identified to be required for maintaining the integrity of the glomerular filtration barrier. It is an integral transmembrane protein of 99 amino acids with three transmembrane domains. TMEM14A has been implied to suppress Bax-mediated apoptosis in other studies. Other than that, little is currently known of its function. Here, we show that its expression is diminished before onset of proteinuria in a spontaneously proteinuric rat model. Knocking down tmem14a mRNA translation results in proteinuria in zebrafish embryos without affecting tubular reabsorption. Also, it is primarily expressed by podocytes. Lastly, an increase in glomerular TMEM14A expression is exhibited in various proteinuric renal diseases. Overall, these results suggest that TMEM14A is a novel factor in the protective mechanisms of the nephron to maintain glomerular filtration barrier integrity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Podócitos
/
Proteínas Reguladoras de Apoptose
/
Barreira de Filtração Glomerular
/
Proteínas de Membrana
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article