Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.

Chang, Meng; Min, Yuan-Qin; Xu, Zhao; Deng, Fei; Wang, Hualin; Ning, Yun-Jia

Chang, Meng; Min, Yuan-Qin; Xu, Zhao; Deng, Fei; Wang, Hualin; Ning, Yun-Jia.

Afiliação

Chang M; Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Min Y-Q; University of Chinese Academy of Sciences, Beijing, China.
Xu Z; Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Deng F; State Key Laboratory of Virology and Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Wang H; Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Ning Y-J; University of Chinese Academy of Sciences, Beijing, China.

J Virol ; 98(1): e0156823, 2024 Jan 23.

Article em En | MEDLINE | ID: mdl-38054738

Assuntos

Phlebovirus; Febre Grave com Síndrome de Trombocitopenia; Humanos; Proteínas do Nucleocapsídeo; Ribonucleoproteínas/metabolismo; RNA Polimerase Dependente de RNA; Febre Grave com Síndrome de Trombocitopenia/metabolismo; Febre Grave com Síndrome de Trombocitopenia/virologia; Phlebovirus/fisiologia; Interações Hospedeiro-Patógeno

Palavras-chave

Dabie bandavirus (DBV); MxA; SFTSV; emerging virus; host restriction factor; nucleocapsid protein (NP); ribonucleoprotein (RNP); virus-host interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Phlebovirus / Febre Grave com Síndrome de Trombocitopenia Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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