Polygenic Risk of Mental Disorders and Subject-Specific School Grades.

Jefsen, Oskar Hougaard; Holde, Katrine; McGrath, John J; Rajagopal, Veera Manikandan; Albiñana, Clara; Vilhjálmsson, Bjarni Jóhann; Grove, Jakob; Agerbo, Esben; Yilmaz, Zeynep; Plana-Ripoll, Oleguer; Munk-Olsen, Trine; Demontis, Ditte; Børglum, Anders; Mors, Ole; Bulik, Cynthia M; Mortensen, Preben Bo; Petersen, Liselotte Vogdrup

Jefsen, Oskar Hougaard; Holde, Katrine; McGrath, John J; Rajagopal, Veera Manikandan; Albiñana, Clara; Vilhjálmsson, Bjarni Jóhann; Grove, Jakob; Agerbo, Esben; Yilmaz, Zeynep; Plana-Ripoll, Oleguer; Munk-Olsen, Trine; Demontis, Ditte; Børglum, Anders; Mors, Ole; Bulik, Cynthia M; Mortensen, Preben Bo; Petersen, Liselotte Vogdrup.

Afiliação

Jefsen OH; Psychosis Research Unit, Aarhus University Hospital, Psychiatry, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: oskar.jefsen@clin.au.dk.
Holde K; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
McGrath JJ; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia; Queensland Brain Institute, University of Queensland, St. Lucia, Brisbane, Queensland, Australia.
Rajagopal VM; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
Albiñana C; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Vilhjálmsson BJ; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Grove J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
Agerbo E; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Researc
Yilmaz Z; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Plana-Ripoll O; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Munk-Olsen T; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Demontis D; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Børglum A; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
Mors O; Psychosis Research Unit, Aarhus University Hospital, Psychiatry, Aarhus, Denmark.
Bulik CM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Mortensen PB; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Petersen LV; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.

Biol Psychiatry ; 2023 Dec 05.

Article em En | MEDLINE | ID: mdl-38061465

ABSTRACT

ABSTRACT

BACKGROUND:

Education is essential for socioeconomic security and long-term mental health; however, mental disorders are often detrimental to the educational trajectory. Genetic correlations between mental disorders and educational attainment do not always align with corresponding phenotypic associations, implying heterogeneity in the genetic overlap.

METHODS:

We unraveled this heterogeneity by investigating associations between polygenic risk scores for 6 mental disorders and fine-grained school

outcomes:

school grades in language and mathematics in ninth grade and high school, as well as educational attainment by age 25, using nationwide-representative data from established cohorts (N = 79,489).

RESULTS:

High polygenic liability of attention-deficit/hyperactivity disorder was associated with lower grades in language and mathematics, whereas high polygenic risk of anorexia nervosa or bipolar disorder was associated with higher grades in language and mathematics. Associations between polygenic risk and school grades were mixed for schizophrenia and major depressive disorder and neutral for autism spectrum disorder.