Biological variation of inflammatory and iron metabolism markers in high-endurance recreational athletes; are these markers useful for athlete monitoring?
Clin Chem Lab Med
; 62(5): 844-852, 2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38062926
ABSTRACT
OBJECTIVES:
To deliver biological variation (BV) data for serum hepcidin, soluble transferrin receptor (sTfR), erythropoietin (EPO) and interleukin 6 (IL-6) in a population of well-characterized high-endurance athletes, and to evaluate the potential influence of exercise and health-related factors on the BV.METHODS:
Thirty triathletes (15 females) were sampled monthly (11 months). All samples were analyzed in duplicate and BV estimates were delivered by Bayesian and ANOVA methods. A linear mixed model was applied to study the effect of factors related to exercise, health, and sampling intervals on the BV estimates.RESULTS:
Within-subject BV estimates (CVI) were for hepcidin 51.9â¯% (95â¯% credibility interval 46.9-58.1), sTfR 10.3â¯% (8.8-12) and EPO 27.3â¯% (24.8-30.3). The mean concentrations were significantly different between sex, but CVI estimates were similar and not influenced by exercise, health-related factors, or sampling intervals. The data were homogeneously distributed for EPO but not for hepcidin or sTfR. IL-6 results were mostly below the limit of detection. Factors related to exercise, health, and sampling intervals did not influence the BV estimates.CONCLUSIONS:
This study provides, for the first time, BV data for EPO, derived from a cohort of well-characterized endurance athletes and indicates that EPO is a good candidate for athlete follow-up. The application of the Bayesian method to deliver BV data illustrates that for hepcidin and sTfR, BV data are heterogeneously distributed and using a mean BV estimate may not be appropriate when using BV data for laboratory and clinical applications.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Interleucina-6
/
Hepcidinas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article