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The Compensation Index Is Better Associated with DSA ASITN Collateral Score Compared to the Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio.
Lakhani, Dhairya A; Balar, Aneri B; Koneru, Manisha; Wen, Sijin; Hoseinyazdi, Meisam; Greene, Cynthia; Xu, Risheng; Luna, Licia; Caplan, Justin; Dmytriw, Adam A; Guenego, Adrien; Wintermark, Max; Gonzalez, Fernando; Urrutia, Victor; Huang, Judy; Nael, Kambiz; Rai, Ansaar T; Albers, Gregory W; Heit, Jeremy J; Yedavalli, Vivek S.
Afiliação
  • Lakhani DA; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Balar AB; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Koneru M; Cooper Medical School, Rowan University, Camden, NJ 08028, USA.
  • Wen S; Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.
  • Hoseinyazdi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Greene C; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Xu R; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Luna L; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Caplan J; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Dmytriw AA; Department of Radiology, Harvard Medical School, Boston, MA 02115, USA.
  • Guenego A; Department of Radiology, Université Libre De Bruxelles Hospital Erasme, 1070 Anderlecht, Belgium.
  • Wintermark M; Department of Radiology, University of Texas, MD Anderson Center, Houston, TX 77030, USA.
  • Gonzalez F; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Urrutia V; Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Huang J; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Nael K; Division of Neuroradiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Rai AT; Department of Radiology, West Virginia University, Morgantown, WV 26506, USA.
  • Albers GW; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94063, USA.
  • Heit JJ; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94063, USA.
  • Yedavalli VS; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
J Clin Med ; 12(23)2023 Nov 28.
Article em En | MEDLINE | ID: mdl-38068416
BACKGROUND: Pretreatment CT Perfusion (CTP) parameters serve as reliable surrogates of collateral status (CS). In this study, we aim to assess the relationship between the novel compensation index (CI, Tmax > 4 s/Tmax > 6 s) and already established CTP collateral markers, namely cerebral blood volume (CBV) index and Hypoperfusion Intensity Ratio (HIR), with the reference standard American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score (CS) on DSA. METHODS: In this retrospective study, inclusion criteria were the following: (a) CT angiography confirmed anterior circulation large vessel occlusion from 9 January 2017 to 10 January 2023; (b) diagnostic CT perfusion; and (c) underwent mechanical thrombectomy with documented DSA-CS. Student t-test, Mann-Whitney-U-test and Chi-square test were used to assess differences. Spearman's rank correlation and logistic regression analysis were used to assess associations. p ≤ 0.05 was considered significant. RESULTS: In total, 223 patients (mean age: 67.8 ± 15.8, 56% female) met our inclusion criteria. The CI (ρ = 0.37, p < 0.001) and HIR (ρ = -0.29, p < 0.001) significantly correlated with DSA-CS. Whereas the CBV Index (ρ = 0.1, p > 0.05) did not correlate with DSA-CS. On multivariate logistic regression analysis taking into account age, sex, ASPECTS, tPA, premorbid mRS, NIH stroke scale, prior history of TIA, stroke, atrial fibrillation, diabetes mellitus, hyperlipidemia, heart disease and hypertension, only CI was not found to be independently associated with DSA-CS (adjusted OR = 1.387, 95% CI: 1.09-1.77, p < 0.01). CONCLUSION: CI demonstrates a stronger correlation with DSA-CS compared to both the HIR and CBV Index where it may show promise as an additional quantitative pretreatment CS biomarker.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article