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Early itch relief with upadacitinib predicts later skin clearance in Atopic dermatitis.
Hagino, Teppei; Yoshida, Mai; Hamada, Risa; Saeki, Hidehisa; Fujimoto, Eita; Kanda, Naoko.
Afiliação
  • Hagino T; Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
  • Yoshida M; Department of Dermatology, Nippon Medical School, Tokyo, Japan.
  • Hamada R; Department of Dermatology, Nippon Medical School, Tokyo, Japan.
  • Saeki H; Department of Dermatology, Nippon Medical School, Tokyo, Japan.
  • Fujimoto E; Department of Dermatology, Fujimoto Dermatology Clinic, Funabashi, Japan.
  • Kanda N; Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
J Dermatolog Treat ; 35(1): 2291317, 2024 Dec.
Article em En | MEDLINE | ID: mdl-38073560
ABSTRACT

BACKGROUND:

Though Janus kinase inhibitors such as upadacitinib rapidly relieve itch in atopic dermatitis (AD) patients, how early itch relief impacts later skin clearance is not examined.

OBJECTIVES:

This study aims to determine if early itch relief by upadacitinib could predict complete skin clearance in later phases.

METHODS:

This retrospective study involved 105 patients with moderate-to-severe AD treated with upadacitinib 15 mg/day. Eczema area and severity index (EASI), atopic dermatitis control tool, and achievement rate of EASI 100 were evaluated at weeks 4, 12, and 24. The threshold of early peak pruritus-numerical rating scale (PP-NRS) predicting later skin clearance was assessed by area under the receiver-operating characteristic curve, and predictors for EASI 100 achievement were determined by logistic regression analysis.

RESULTS:

The rate of achieving EASI 100 at week 24 was extremely higher in patients who achieved week 2 PP-NRS ≤ 1 (42.9%) than in non-achievers (1.4%). The logistic regression analysis showed that the achievement of week 2 PP-NRS ≤ 1 and low body mass index were associated with achievement of EASI 100 at weeks 12 and 24.

CONCLUSIONS:

The achievement of week 2 PP-NRS ≤ 1 may predict later skin clearance in upadacitinib treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatite Atópica Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatite Atópica Idioma: En Ano de publicação: 2024 Tipo de documento: Article