Transcriptional Plasticity Drives IMiD and p300 Inhibitor Resistance in Multiple Myeloma.
Blood Cancer Discov
; 5(1): 5-7, 2024 01 08.
Article
em En
| MEDLINE
| ID: mdl-38085608
ABSTRACT
SUMMARY:
In this issue of Blood Cancer Discovery, Neri, Barwick, and colleagues and Welsh, Barwick, and colleagues performed RNA sequencing, chromatin immunoprecipitation sequencing, assay for transposase-accessible chromatin using sequencing, and genetic studies to characterize the underlying mechanisms of immunomodulatory drug (IMiD) resistance in multiple myeloma. They demonstrated that IMiD resistance is driven by sustained expression of MYC and IRF4 via transcriptional plasticity that involves induction of ETV4 and BATF proteins, the binding of these proteins to their super-enhancers, and the recruitment of BRD4 and p300. Finally, these studies suggest IMiD and p300 inhibitor combination as a promising therapeutic strategy in multiple myeloma. See related article by Neri, Barwick, et al., p. 56 (9). See related article by Welsh, Barwick, et al., p. 34 (10).
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Base de dados:
MEDLINE
Assunto principal:
Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article