New methods to investigate the GnRH pulse generator.
J Mol Endocrinol
; 72(2)2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-38085702
ABSTRACT
The exact neural construct underlying the dynamic secretion of gonadotrophin-releasing hormone (GnRH) has only recently been identified despite the detection of multiunit electrical activity volleys associated with pulsatile luteinising hormone (LH) secretion four decades ago. Since the discovery of kisspeptin/neurokinin B/dynorphin neurons in the mammalian hypothalamus, there has been much research into the role of this neuronal network in controlling the oscillatory secretion of gonadotrophin hormones. In this review, we provide an update of the progressive application of cutting-edge techniques combined with mathematical modelling by the neuroendocrine community, which are transforming the functional investigation of the GnRH pulse generator. Understanding the nature and function of the GnRH pulse generator can greatly inform a wide range of clinical studies investigating infertility treatments.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hormônio Luteinizante
/
Hormônio Liberador de Gonadotropina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article