Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed CâH amidation.

Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed CâH amidation.

Antermite, Daniele; Friis, Stig D; Johansson, Johan R; Putra, Okky Dwichandra; Ackermann, Lutz; Johansson, Magnus J.

Afiliação

Antermite D; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Friis SD; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Johansson JR; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Putra OD; Early Product Development and Manufacturing, Pharmaceutical Sciences R&D, AstraZeneca, Gothenburg, Sweden.
Ackermann L; Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de.
Johansson MJ; German Center for Cardiovascular Research (DZHK), Berlin, Germany. lutz.ackermann@chemie.uni-goettingen.de.

Nat Commun ; 14(1): 8222, 2023 Dec 12.

Article em En | MEDLINE | ID: mdl-38086825

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article