A. castellanii and P. aeruginosa mutually exacerbate damage to corneal cells during coinfection.
Microbiol Spectr
; 12(1): e0268323, 2024 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-38095463
ABSTRACT
IMPORTANCE At the National Cheng Kung University Hospital, numerous cases of amoebic keratitis had been identified with concurrent bacterial infections. Among these bacterial coinfections, Pseudomonas aeruginosa accounted for 50% of the reported cases. However, the impact of pathogenic bacteria on amoeba-induced corneal damage remains unclear. In our study, we successfully demonstrated that P. aeruginosa accumulated on the Acanthamoeba castellanii surface and caused more severe corneal damage. We also indicated that the exposure of P. aeruginosa to amoeba-soluble antigens enhanced its adhesion ability, promoted biofilm formation, and led to more severe corneal cell damage. These findings significantly contributed to our understanding of the risk associated with P. aeruginosa coinfection in the progression of amoeba keratitis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Coinfecção
/
Lesões da Córnea
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Ceratite
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article