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Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.
Ding, Chengyi; Ng Fat, Linda; Britton, Annie; Im, Pek Kei; Lin, Kuang; Topiwala, Anya; Li, Liming; Chen, Zhengming; Millwood, Iona Y; Bell, Steven; Mehta, Gautam.
Afiliação
  • Ding C; Division of Psychiatry, University College London, London, UK.
  • Ng Fat L; Research Department of Epidemiology and Public Health, University College London, London, UK.
  • Britton A; Research Department of Epidemiology and Public Health, University College London, London, UK.
  • Im PK; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Topiwala A; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
  • Chen Z; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
  • Millwood IY; Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China.
  • Bell S; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Mehta G; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Nat Commun ; 14(1): 8041, 2023 Dec 14.
Article em En | MEDLINE | ID: mdl-38097541
ABSTRACT
Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Consumo Excessivo de Bebidas Alcoólicas / Hepatopatias Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Consumo Excessivo de Bebidas Alcoólicas / Hepatopatias Idioma: En Ano de publicação: 2023 Tipo de documento: Article