Engineered methane biocatalysis: strategies to assimilate methane for chemical production.
Curr Opin Biotechnol
; 85: 103031, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38101295
ABSTRACT
Methane (CH4), one of the greenhouse gases, is considered a promising feedstock for the biological production of fuels and chemicals. Although recent studies have demonstrated the capability of methanotrophs to convert CH4 into various bioproducts by metabolic engineering, the productivity has not reached commercial levels. As such, there is a growing interest in synthetic methanotrophic systems as an alternative. This review summarizes the strategies for enhancing native CH4 assimilation and discusses the challenges for the construction of synthetic methanotrophy into nonmethanotrophic industrial strains. Additionally, we suggest a mixed heterotrophic approach that integrates CH4 assimilation with glucose and xylose metabolism to improve productivity. The synthetic methanotrophic system presented in this review could pave the way for sustainable and efficient biomanufacturing using CH4.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Xilose
/
Metano
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article