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Menopause and accelerated aortic stiffness.
O'Neill, Sheila M; Travers, Catherine M; Otahal, Petr; Khoo, Soo-Keat; Sharman, James E.
Afiliação
  • O'Neill SM; Betty Byrne Henderson Women's Health Research Centre, Royal Brisbane & Women's Hospital, Brisbane, Australia; Australian National University, Canberra, Australian Capital Territory, Australia. Electronic address: sheila.o'neill@anu.edu.au.
  • Travers CM; Betty Byrne Henderson Women's Health Research Centre, Royal Brisbane & Women's Hospital, Brisbane, Australia; School of Health & Rehabilitation Sciences, University of Queensland Australia, Australia.
  • Otahal P; Menzies Institute for Medical Research, University of Tasmania, Australia.
  • Khoo SK; Betty Byrne Henderson Women's Health Research Centre, Royal Brisbane & Women's Hospital, Brisbane, Australia; Mayne Academy of Obstetrics & Gynaecology, Faculty of Medicine, University of Queensland, Australia.
  • Sharman JE; Menzies Institute for Medical Research, University of Tasmania, Australia.
Maturitas ; 180: 107900, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38101308
ABSTRACT

BACKGROUND:

The menopausal transition is widely believed to increase the risk of cardiovascular disease, based on the notion that estrogen is cardioprotective in women. While aortic stiffness is an independent predictor of cardiovascular disease, it has been unclear whether this risk increases during menopause.

OBJECTIVE:

This study aimed to determine the association between changes in menopausal status and aortic stiffness. MAIN OUTCOME

MEASURES:

Menopausal status was classified using the Stages of Reproductive Aging in Women criteria in a stratified random sample of Australian women aged 40-80 years, at three time-points over 14 years (n = 469 in 2001-02 and 2005, and n = 323 in 2014). Aortic stiffness was measured non-invasively via carotid-femoral pulse wave velocity at each time point. Mixed modeling was employed to determine the independent associations between menopausal status and aortic stiffness accounting for multiple covariates including age, systolic blood pressure, heart rate, medications, cholesterol, waist circumference, smoking and diabetes status.

RESULTS:

There was no evidence to support an association between the menopausal transition and an acceleration of aortic stiffness. However, there was an acceleration of aortic stiffness in the late (8+ years) postmenopause phase, after accounting for age and traditional cardiovascular risk factors (0.122 [95%CI 0.106, 0.139] m/s/year; p < 0.001).

CONCLUSIONS:

The menopausal transition is not associated with major changes in aortic stiffness beyond normal age-related effects. However, the clinically significant acceleration in aortic stiffness observed in late postmenopause may contribute to greater cardiovascular risk in this later life phase. Study registered in the Australian and New Zealand Clinical Trials Registry, reference ACTRN12618000005257.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Rigidez Vascular Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Rigidez Vascular Idioma: En Ano de publicação: 2024 Tipo de documento: Article