TRAPs: the 'elevator-with-an-operator' mechanism.
Trends Biochem Sci
; 49(2): 134-144, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38102017
ABSTRACT
Tripartite ATP-independent periplasmic (TRAP) transporters are nutrient-uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate-binding protein (SBP) to an elevator-type secondary transporter, which is a first-of-its-kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Proteínas de Bactérias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article