Screening for molecular glues - Challenges and opportunities.
SLAS Discov
; 29(2): 100136, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38104659
ABSTRACT
Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemical properties that aim to stabilise the interaction between two proteins. Most often this approach is used to improve or induce an interaction between the target and an E3 ligase, but other interactions which stabilise interactions to increase activity or to inhibit binding to a natural effector have also been demonstrated. This review will describe the effects of induced proximity, discuss current methods used to identify molecular glues and introduce approaches that could be adapted for molecular glue screening.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Ubiquitina-Proteína Ligases
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article