N-containing phenolic compounds from Periplaneta americana with triple negative breast cancer inhibitory activity.
Phytochemistry
; 218: 113936, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38104748
ABSTRACT
Eight previously undescribed compounds comprising pyrrole-2-carboxaldehyde derivatives, namely periplanpyrroles A-D (1-4), spirooxindole derivatives perispirooxindoles A (5) and B (6), and the phenolic compounds periplanetols G (7) and H (8), along with eight known compounds were isolated from the 70% ethanol extract of the whole bodies of Periplaneta americana. Their structures including absolute configurations were unambiguously identified by comprehensive spectroscopic analyses and computational methods. In addition, all compounds were evaluated for their activities against triple negative breast cancer in vitro. The wound healing assay revealed that 7, 9, and 11 significantly inhibit the migration of BT549 and MDA-MB-231 cells. Further observations made in Western blotting experiments showed that 7 could dose-dependently decrease the protein level of vimentin and N-cadherin in MDA-MB-231 and BT549 cells.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Periplaneta
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Compostos de Espiro
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Benzopiranos
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Neoplasias de Mama Triplo Negativas
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Oxindóis
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Nitrilas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article