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Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.
Ukraintseva, Svetlana; Duan, Hongzhe; Holmes, Rachel; Bagley, Olivia; Wu, Deqing; Yashkin, Arseniy; Kulminski, Alexander; Akushevich, Igor; Whitson, Heather; Stallard, Eric; Yashin, Anatoliy; Arbeev, Konstantin.
Afiliação
  • Ukraintseva S; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Duan H; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Holmes R; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Bagley O; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Wu D; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Yashkin A; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Kulminski A; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Akushevich I; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Whitson H; Center for Aging and Human Development, Duke University, Durham, NC, USA.
  • Stallard E; Geriatrics Research, Education, and Clinical Center (GRECC), Durham VA Medical Center, Durham, NC, USA.
  • Yashin A; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
  • Arbeev K; Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
J Alzheimers Dis ; 97(1): 163-170, 2024.
Article em En | MEDLINE | ID: mdl-38108347
ABSTRACT
Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2024 Tipo de documento: Article