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Adrenocorticotropin-Dependent Ectopic Cushing's Syndrome: A Case Report.
Rebelo Matos, André; Martins, André; Barbosa, Maria J; Quinteiro, Inês; Faustino, Diogo; Gameiro, Rita; Azevedo, Luísa.
Afiliação
  • Rebelo Matos A; Internal Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
  • Martins A; Internal Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
  • Barbosa MJ; Internal Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
  • Quinteiro I; Critical Care Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
  • Faustino D; Internal Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
  • Gameiro R; Internal Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
  • Azevedo L; Internal Medicine Department, Hospital São José, Centro Hospitalar Universitário de Lisboa Central, Entidades Públicas Empresariais (EPE), Lisbon, PRT.
Cureus ; 15(11): e49124, 2023 Nov.
Article em En | MEDLINE | ID: mdl-38125241
ABSTRACT
Paraneoplastic syndromes are rare and diverse conditions caused by either an abnormal chemical signaling molecule produced by tumor cells or a body's immune response against the tumor itself. These syndromes can manifest in a variable, multisystemic and often nonspecific manner posing a diagnostic challenge. We report the case of an 81-year-old woman who exhibited severe hypokalemia, metabolic alkalosis, and worsening hyperglycemia. The investigation was consistent with adrenocorticotropin (ACTH)-dependent Cushing's syndrome and, eventually, the patient was diagnosed with stage IV primary small-cell lung cancer (SCLC). SCLC is known to be associated with paraneoplastic syndromes, including Cushing's syndrome caused by ectopic adrenocorticotropin (ACTH) secretion. Despite being associated with very poor outcomes, managing these syndromes can be challenging and may hold prognostic significance.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article