Pasireotide: potential treatment option for McCune-Albright-associated acromegaly.
Eur J Endocrinol
; 190(1): K17-K20, 2024 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-38128124
ABSTRACT
Only 30% of patients with McCune-Albright syndrome (MAS)-associated acromegaly achieve biochemical control under first-generation somatostatin receptor ligands (fg-SRLs), while pegvisomant fails to normalize insulin-like growth factor 1 (IGF-I) in >20% of cases. Here, we report all the patients with MAS-associated acromegaly treated with pasireotide long-acting release (LAR) in our center. Pasireotide LAR 20â
mg/month resulted in rapid and long-term IGF-I normalization in patients #1 and #3. Patient #3 was resistant to fg-SRLs, while patient #1 was also controlled on fg-SRLs. In patient #2, resistant to fg-SRLs and uncontrolled on pegvisomant 40â
mg/day combined with cabergoline 0.5â
mg/day, pegvisomant was replaced with pasireotide LAR 40â
mg/month, resulting in the near normalization of IGF-I levels. All 3 patients developed intermittent impaired fasting glucose, without the need for glucose-lowering drugs. Thus, pasireotide LAR is clearly useful as third-line therapy, and potentially even as second-line therapy, in MAS-associated acromegaly.
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Base de dados:
MEDLINE
Assunto principal:
Acromegalia
/
Hormônio do Crescimento Humano
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article