Your browser doesn't support javascript.
loading
Clinical factors influencing olfactory performance in patients with persistent COVID-19 smell loss longer than 1 year.
Pendolino, Alfonso Luca; Ottaviano, Giancarlo; Navaratnam, Annakan V; Scarpa, Bruno; Andrews, Peter J.
Afiliação
  • Pendolino AL; Department of ENT Royal National ENT & Eastman Dental Hospitals London UK.
  • Ottaviano G; Ear Institute, UCL London UK.
  • Navaratnam AV; Department of Neurosciences, Otolaryngology Section University of Padova Padova Italy.
  • Scarpa B; Department of ENT Royal National ENT & Eastman Dental Hospitals London UK.
  • Andrews PJ; Department of Statistical Sciences and Department of Mathematics Tullio Levi-Civita University of Padova Padova Italy.
Laryngoscope Investig Otolaryngol ; 8(6): 1449-1458, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38130252
ABSTRACT

Objectives:

Factors affecting persistence of COVID-19-related olfactory dysfunction (OD) remain partially unknown. We aim to evaluate the clinical factors which could influence olfactory performance in patients with persistent COVID-19-related smell loss.

Methods:

A retrospective analysis of 100 patients with persistent COVID-19-related OD was performed between October 2020 and December 2022 at a single-center long-COVID smell clinic. All subjects underwent smell assessment using Sniffin' Sticks (S'S) extended test, nasal endoscopy, nasal airflow evaluation (peak nasal inspiratory flow [PNIF]), allergy test (skin prick test [SPT]) for common aeroallergens, MRI of the head and patient-reported outcome measures (PROMs-VAS, SF-36, Short QOD-NS, SNOT-22). Based on S'S score, subjects were divided into normosmics (TDI ≥ 30.75) and dysosmics (TDI < 30.75).

Results:

The median age was 42 years and the median length of patient-reported OD was 1.4 years. 20 patients (20.0%) were normosmic at the time of S'S assessment. Dysosmic patients were found to have significantly lower scores at the SF-36 health domains for energy/fatigue (p = .0004) and emotional wellbeing (p = .04) when compared to normosmics. A moderate correlation (r = .45-.59) between S'S scores and some PROMs was also demonstrated. At the multivariate analysis higher PNIF scores positively influenced odor threshold (p = .001) while positivity to SPT negatively influenced odor identification (p = .04).

Conclusions:

Impairment of nasal airflow and sensitivity to aeroallergens can negatively affect olfactory performance in COVID-19-related OD. Long-COVID smell loss deeply affects QoL although recovery of olfaction can bring it back to a normal range. Level of Evidence IV.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article