Clinical and Histopathologic Spectrum of Toxic Erythema of Chemotherapy: A Series of 56 Cases From a Single Institution.
Am J Dermatopathol
; 46(6): 337-345, 2024 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-38133527
ABSTRACT
INTRODUCTION:
Although many individual cases and small series of toxic erythema of chemotherapy (TEC) have been described, the full spectrum of findings is not well understood.OBJECTIVE:
To provide a comprehensive review of the clinical and histopathologic features of TEC with an emphasis on novel histopathologic findings.METHODS:
We searched our electronic medical record for "toxic erythema of chemotherapy" or "neutrophilic eccrine hidradenitis." Fifty-six cases meeting clinical and histopathologic criteria were identified. The electronic medical record and accompanying hematoxylin and eosin-stained slides were retrospectively reviewed.RESULTS:
The clinical findings were heterogeneous but included classic presentations such as intertriginous eruptions (34%) and acral erythema (25%). The most common histopathologic features were apoptotic keratinocytes (95%), basal vacuolar change (91%), and epithelial dysmaturation (79%). Eccrine squamous syringometaplasia was seen in over half of the cases (33/56; 59%), whereas neutrophilic eccrine hidradenitis was uncommon (16%). Interestingly, many cases showed prominent interstitial histiocytes (55%). Other novel findings included irregular orthohyperkeratosis (23%), irregular epidermal hyperplasia (14%), and acantholysis (9%).LIMITATIONS:
As a retrospective study, it is subject to information bias.CONCLUSION:
This is the largest reported series of TEC. In addition to confirming previously reported features, we identify novel histopathologic findings to add to the spectrum of TEC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Toxidermias
/
Eritema
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article