The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia.
Ann Hematol
; 2023 Dec 27.
Article
em En
| MEDLINE
| ID: mdl-38148344
ABSTRACT
The E2A-PBX1 gene fusion is a common translocation in B-cell acute lymphoblastic leukaemia. Patients harbouring the E2A-PBX1 fusion gene typically exhibit an intermediate prognosis. Furthermore, minimal residual disease has unsatisfactory prognostic value in E2A-PBX1 B-cell acute lymphoblastic leukaemia. However, the mechanism of E2A-PBX1 in the occurrence and progression of B-cell acute lymphoblastic leukaemia is not well understood. Here, we mainly review the roles of E2A and PBX1 in the differentiation and development of B lymphocytes, the mechanism of E2A-PBX1 gene fusion in B-cell acute lymphoblastic leukaemia, and the potential therapeutic approaches.
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MEDLINE
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En
Ano de publicação:
2023
Tipo de documento:
Article