Methylene Insertion into Nitrogen-Heteroatom Single Bonds of 1,2-Azoles via a Zinc Carbenoid: An Alternative Tool for Skeletal Editing.
Adv Sci (Weinh)
; 11(10): e2307563, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38148471
ABSTRACT
The nitrogen-heteroatom single bonds of 1,2-azoles and isoxazolines underwent methylene insertion in the presence of CH2 I2 (6 equiv.) and diethylzinc (3 equiv.) to produce a wide variety of the ring-expanded six-membered heterocycles. Density functional theory calculations suggest that the methylene insertion proceeds via cleavage of nitrogen-heteroatom single bonds followed by ring closure.
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MEDLINE
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En
Ano de publicação:
2024
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Article