Renal Epithelial Mitochondria: Implications for Hypertensive Kidney Disease.
Compr Physiol
; 14(1): 5225-5242, 2023 12 29.
Article
em En
| MEDLINE
| ID: mdl-38158371
ABSTRACT
According to the Centers for Disease Control and Prevention, 1 in 2 U.S. adults have hypertension, and more than 1 in 7 chronic kidney disease. In fact, hypertension is the second leading cause of kidney failure in the United States; it is a complex disease characterized by, leading to, and caused by renal dysfunction. It is well-established that hypertensive renal damage is accompanied by mitochondrial damage and oxidative stress, which are differentially regulated and manifested along the nephron due to the diverse structure and functions of renal cells. This article provides a summary of the relevant knowledge of mitochondrial bioenergetics and metabolism, focuses on renal mitochondrial function, and discusses the evidence that has been accumulated regarding the role of epithelial mitochondrial bioenergetics in the development of renal tissue dysfunction in hypertension. © 2024 American Physiological Society. Compr Physiol 145225-5242, 2024.
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1
Base de dados:
MEDLINE
Assunto principal:
Hipertensão
/
Hipertensão Renal
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article