Regio- and Stereoselective Hexafluoroisopropoxylation and Trifluoroethoxylation of Allenamides.

ABSTRACT

Incorporating fluorinated moieties into organic molecules is an attractive strategy to enhance drug-like properties. Herein, we have developed a simple and self-promoted protocol for hexafluoroisopropoxylation and trifluoroethoxylation of allenamides with fluorinated alcohols such as HFIP and TFE. The reaction provided the fluoroalkoxylated products in a regio- and stereoselective manner in good to moderate yields under mild conditions.