Treatment of the most difficult-to-cure hepatitis C virus-infected population with sofosbuvir / velpatasvir.
Pol Arch Intern Med
; 134(2)2024 02 28.
Article
em En
| MEDLINE
| ID: mdl-38164647
ABSTRACT
INTRODUCTION:
Pangenotypic therapies for infections with hepatitis C virus (HCV), although universal and highly effective, entail a risk of treatment failure.OBJECTIVES:
Our study aimed to identify the population of HCVinfected patients most difficult to cure with the sofosbuvir / velpatasvir (SOF/VEL) regimen. PATIENTS ANDMETHODS:
The effectiveness of the SOF/VEL regimen with a possible addition of ribavirin (RBV) was evaluated in populations known to be less responsive to treatment, and then in a population characterized by the combination of all factors impairing effectiveness, comprising patients treated with this regimen in the EpiTer2 multicenter retrospective study.RESULTS:
A total of 2267 patients were treated with SOF/VEL±RBV. Of those, 2078 (96.4%) achieved sustained virologic response. The cure rate was 93.5% among 646 patients infected with genotype (GT) 3, 92.3% among 635 patients with cirrhosis, 95.5% in a population of 1233 men, and 94.1% among 421 patients with body mass index (BMI) above 30. An analysis in a group of 43 men with cirrhosis and obesity infected with GT3 showed the effectiveness of pangenotypic therapy at only 79.1%, falling to 66.7% in individuals with previous treatment failure.CONCLUSIONS:
In a large population of SOF/VELtreated HCVinfected patients, we showed relatively low effectiveness of the regimen in treatmentexperienced men with cirrhosis and obesity, infected with GT3. Triple therapy should be considered when initiating the treatment of HCV infections in this group, which, however, needs to be confirmed in further studies. Previous studies were conducted in less demanding populations, because they did not take into account sex and BMI, which significantly affect the treatment effectiveness.
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Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Benzopiranos
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Carbamatos
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Hepatite C
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Sofosbuvir
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Compostos Heterocíclicos de 4 ou mais Anéis
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article