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Revealing the elevation of Zn2+ in the brain of depressed mice by a ratiometric fluorescent probe with dual near-infrared emissions.
Jin, Haobin; Ju, Can; Duan, Chenxu; Zhang, Ningwen; Cao, Yongyong; Xia, Qineng; Zhou, Jin; Gao, Shumei; Wang, Yangang; Huang, Hong.
Afiliação
  • Jin H; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Ju C; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Duan C; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Zhang N; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Cao Y; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Xia Q; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Zhou J; School of Pharmacy, Weifang Medical University, Weifang 261053, China. zhoujin@wfmc.edu.cn.
  • Gao S; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Wang Y; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
  • Huang H; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. ygwang8136@zjxu.edu.cn.
Chem Commun (Camb) ; 60(9): 1100-1103, 2024 Jan 25.
Article em En | MEDLINE | ID: mdl-38165284
ABSTRACT
A mitochondria-targeted ratiometric fluorescent probe (Mito-Zn) was first designed and synthesized with dual emissions both located in the near-infrared region, for Zn2+ detection with high sensitivity and selectivity. By using the developed Mito-Zn, a high level of Zn2+ in the depressed mouse brain was discovered for the first time.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Corantes Fluorescentes Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Corantes Fluorescentes Idioma: En Ano de publicação: 2024 Tipo de documento: Article