Dihydrophenanthro[b]furan derivatives from the tubers of Bletilla striata.
J Asian Nat Prod Res
; 26(2): 177-188, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38166573
ABSTRACT
Two pairs of new dihydrophenanthro[b]furan enantiomers blephebibnols G-H (1-2), one new dihydrophenanthro[b]furan derivative blephebibnol I (3), along with four known analogues (4-7), were isolated from the tubers of Bletilla striata. Their structures including the absolute configurations were determined by the combination of spectroscopic data analysis, ECD and NMR calculations. Compounds 1a, 1b, and 2b showed inhibition of NO production in LPS-stimulated BV-2 cells, with IC50 values ranging from 4.11 to 14.65 µM. Further mechanistic study revealed that 1a suppressed the phosphorylation of p65 subunit to regulate the NF-κB signaling pathway. In addition, some compounds displayed selective cytotoxic activities against HCT-116, HepG2, A549, or HGC27 cancer cell lines with IC50 values ranging from 0.1 to 8.23 µM.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Orchidaceae
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article