Pneumococcal Extracellular Vesicles Mediate Horizontal Gene Transfer via the Transformation Machinery.
bioRxiv
; 2023 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-38168155
ABSTRACT
Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen Streptococcus pneumoniae (pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria, and in doing so, may promote the spread of drug resistance genes in the population.
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MEDLINE
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En
Ano de publicação:
2023
Tipo de documento:
Article