Engineered and total biosynthesis of fungal specialized metabolites.
Nat Rev Chem
; 8(1): 61-78, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-38172201
ABSTRACT
Filamentous fungi produce a very wide range of complex and often bioactive metabolites, demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent advances in molecular sciences related to fungi have afforded the development of new tools that allow the rational total biosynthesis of highly complex specialized metabolites in a single process. Increasingly, these pathways can also be engineered to produce new metabolites. Engineering can be at the level of gene deletion, gene addition, formation of mixed pathways, engineering of scaffold synthases and engineering of tailoring enzymes. Combination of these approaches with hosts that can metabolize low-value waste streams opens the prospect of one-step syntheses from garbage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vias Biossintéticas
/
Fungos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article