Molecular skin fluorescence imaging: A tool for evaluating early melanoma development.
Pigment Cell Melanoma Res
; 37(3): 372-377, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38178654
ABSTRACT
A novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvß3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% specificity, while identifying dysplastic nevi with the potential for melanoma development.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Melanoma
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article