Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.
Sci Immunol
; 9(91): eadh0152, 2024 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-38181095
ABSTRACT
Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in these tissues. We developed a technique to restrict genetic recombination to regulatory T cells (Tregs) only in skin. Selective depletion of skin Tregs resulted in T cell-mediated inflammation of hair follicles (HFs). Suppression did not rely on CTLA-4, but instead on high-affinity interleukin-2 (IL-2) receptor expression by skin Tregs, functioning exclusively in a cell-extrinsic manner. In a novel model of HF stem cell (HFSC)-driven autoimmunity, we reveal that skin Tregs immunologically protect the HFSC niche. Finally, we used spatial transcriptomics to identify aberrant IL-2 signaling at stromal-HF interfaces in a rare form of human alopecia characterized by HFSC destruction and alopecia areata. Collectively, these results reveal the fundamental biology of Tregs in skin uncoupled from the systemic pool and elucidate a mechanism of self-tolerance.
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1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Reguladores
/
Privilégio Imunológico
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article