The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids.

Bose, Shree; Shen, Xiling

Bose, Shree; Shen, Xiling.

Afiliação

Bose S; Department of Internal Medicine, University of Chicago, Chicago, IL, USA.
Shen X; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA. Electronic address: xiling.shen@terasaki.org.

Cell Stem Cell ; 31(1): 1-2, 2024 01 04.

Article em En | MEDLINE | ID: mdl-38181746

ABSTRACT

ABSTRACT

Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.

Assuntos

Reprogramação Metabólica; Neoplasias Pancreáticas; Humanos; Metabolismo dos Lipídeos; Organoides; Proteínas Proto-Oncogênicas p21(ras)/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Reprogramação Metabólica Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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