Your browser doesn't support javascript.
loading
Aß38 and Aß43 do not differentiate between Alzheimer's disease and cerebral amyloid angiopathy.
Dargvainiene, Justina; Jensen-Kondering, Ulf; Bender, Benjamin; Berg, Daniela; Brüggemann, Norbert; Flüh, Charlotte; Markewitz, Robert; Neumann, Alexander; Röben, Benjamin; Röcken, Christoph; Royl, Georg; Schulte, Claudia; Wandinger, Klaus-Peter; Weiler, Caroline; Margraf, Nils G; Kuhlenbäumer, Gregor.
Afiliação
  • Dargvainiene J; Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Jensen-Kondering U; Department of Neuroradiology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
  • Bender B; Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel University (CAU), Kiel, Germany.
  • Berg D; Department of Radiology, Diagnostical and Interventional Neuroradiology, University Hospital of Tübingen, Tübingen, Germany.
  • Brüggemann N; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel University (CAU), Kiel, Germany.
  • Flüh C; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  • Markewitz R; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
  • Neumann A; Department of Neurosurgery, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel University (CAU), Kiel, Germany.
  • Röben B; Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Röcken C; Department of Neuroradiology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
  • Royl G; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  • Schulte C; Department of Pathology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel University (CAU), Kiel, Germany.
  • Wandinger KP; Department of Pathology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel University (CAU), Kiel, Germany.
  • Weiler C; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
  • Margraf NG; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  • Kuhlenbäumer G; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
Ann Clin Transl Neurol ; 11(3): 806-811, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38186185
ABSTRACT
Differential diagnosis between Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) using cerebrospinal fluid (CSF) biomarkers is challenging. A recent study suggested that the addition of Aß38 and Aß43 to a standard AD biomarker panel (Aß40, Aß42, t-tau, p-tau) to improve the differential diagnosis. We tested this hypothesis in an independent German cohort of CAA and AD patients and controls using the same analytical techniques. We found excellent discrimination between AD and controls and between CAA and controls, but not between AD and CAA. Adding Aß38 and Aß43 to the panel did not improve the discrimination between AD and CAA.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiopatia Amiloide Cerebral / Doença de Alzheimer Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Angiopatia Amiloide Cerebral / Doença de Alzheimer Idioma: En Ano de publicação: 2024 Tipo de documento: Article