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Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men.
Yamaguchi, Shintaro; Irie, Junichiro; Mitsuishi, Masanori; Uchino, Yuichi; Nakaya, Hideaki; Takemura, Ryo; Inagaki, Emi; Kosugi, Shotaro; Okano, Hideyuki; Yasui, Masato; Tsubota, Kazuo; Hayashi, Kaori; Yoshino, Jun; Itoh, Hiroshi.
Afiliação
  • Yamaguchi S; Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Irie J; Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Mitsuishi M; Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Uchino Y; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Nakaya H; Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Takemura R; Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo 160-8582, Japan.
  • Inagaki E; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kosugi S; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Okano H; Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Yasui M; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Tsubota K; Department of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Hayashi K; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Yoshino J; Present address: Tsubota Laboratory, Inc, Tokyo 160-0016, Japan.
  • Itoh H; Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Endocr J ; 71(2): 153-169, 2024 Feb 28.
Article em En | MEDLINE | ID: mdl-38191197
ABSTRACT
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and obesity. Administration of an NAD+ intermediate, nicotinamide mononucleotide (NMN), replenishes intracellular NAD+ levels and mitigates aging- and obesity-associated derangements in animal models. In this human clinical study, we aimed to investigate the safety and effects of 8-week oral administration of NMN on biochemical, metabolic, ophthalmologic, and sleep quality parameters as well as on chronological alterations in NAD+ content in peripheral tissues. An 8-week, single-center, single-arm, open-label clinical trial was conducted. Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast. The 8-week NMN supplementation regimen was well-tolerated; NAD+ levels in peripheral blood mononuclear cells increased over the course of NMN administration. In participants with insulin oversecretion after oral glucose loading, NMN modestly attenuated postprandial hyperinsulinemia, a risk factor for coronary artery disease (n = 3). In conclusion, NMN overall safely and effectively boosted NAD+ biosynthesis in healthy, middle-aged Japanese men, showing its potential for alleviating postprandial hyperinsulinemia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperinsulinismo / NAD Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperinsulinismo / NAD Idioma: En Ano de publicação: 2024 Tipo de documento: Article