Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity.
Nat Commun
; 15(1): 367, 2024 Jan 08.
Article
em En
| MEDLINE
| ID: mdl-38191623
ABSTRACT
SARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While genetic studies can highlight potential drug targets, understanding the heritability of SARS-CoV-2 susceptibility and COVID-19 severity can contextualize their results. To date, loci from meta-analyses explain 1.2% and 5.8% of variation in susceptibility and severity respectively. Here we estimate the importance of shared environment and additive genetic variation to SARS-CoV-2 susceptibility and COVID-19 severity using pedigree data, PCR results, and hospitalization information. The relative importance of genetics and shared environment for susceptibility shifted during the study, with heritability ranging from 33% (95% CI 20%-46%) to 70% (95% CI 63%-74%). Heritability was greater for days hospitalized with COVID-19 (41%, 95% CI 33%-57%) compared to shared environment (33%, 95% CI 24%-38%). While our estimates suggest these genetic architectures are not fully understood, the shift in susceptibility estimates highlights the challenge of estimation during a pandemic, given environmental fluctuations and vaccine introduction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article