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Prospective study design and data analysis in UK Biobank.
Allen, Naomi E; Lacey, Ben; Lawlor, Deborah A; Pell, Jill P; Gallacher, John; Smeeth, Liam; Elliott, Paul; Matthews, Paul M; Lyons, Ronan A; Whetton, Anthony D; Lucassen, Anneke; Hurles, Matthew E; Chapman, Michael; Roddam, Andrew W; Fitzpatrick, Natalie K; Hansell, Anna L; Hardy, Rebecca; Marioni, Riccardo E; O'Donnell, Valerie B; Williams, Julie; Lindgren, Cecilia M; Effingham, Mark; Sellors, Jonathan; Danesh, John; Collins, Rory.
Afiliação
  • Allen NE; UK Biobank Ltd, Stockport, UK.
  • Lacey B; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Lawlor DA; UK Biobank Ltd, Stockport, UK.
  • Pell JP; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Gallacher J; Population Health Science, Bristol Medical School University of Bristol, Bristol, UK.
  • Smeeth L; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  • Elliott P; School of Health and Wellbeing, University of Glasgow, Scotland.
  • Matthews PM; Department of Psychiatry, University of Oxford, Oxford, UK.
  • Lyons RA; Dementias Platform UK, Department of Psychiatry, University of Oxford, Oxford, UK.
  • Whetton AD; London School of Hygiene and Tropical Medicine, London, UK.
  • Lucassen A; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Hurles ME; NIHR Health Protection Research Unit in Chemical Radiation Threats and Hazards, Imperial College London, UK.
  • Chapman M; UK Dementia Research Centre Institute and Department of Brain Sciences, Imperial College London, London, UK.
  • Roddam AW; Population Data Science, Swansea University Medical School, Swansea, Wales.
  • Fitzpatrick NK; Veterinary Health Innovation Engine, University of Surrey, Guildford, UK.
  • Hansell AL; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Hardy R; Faculty of Medicine, Southampton University, Southampton, UK.
  • Marioni RE; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
  • O'Donnell VB; NHS England, London, UK.
  • Williams J; Our Future Health, London, UK.
  • Lindgren CM; Institute of Health Informatics, University College London, London, UK.
  • Effingham M; Centre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.
  • Sellors J; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
  • Danesh J; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland.
  • Collins R; School of Medicine, Cardiff University, Cardiff, Wales.
Sci Transl Med ; 16(729): eadf4428, 2024 Jan 10.
Article em En | MEDLINE | ID: mdl-38198570
ABSTRACT
Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bancos de Espécimes Biológicos / Biobanco do Reino Unido Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bancos de Espécimes Biológicos / Biobanco do Reino Unido Idioma: En Ano de publicação: 2024 Tipo de documento: Article