The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
Eur J Med Chem
; 265: 115989, 2024 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-38199163
ABSTRACT
Formyl peptide receptors (FPRs) comprise a class of chemoattractant pattern recognition receptors, for which several physiological functions like host-defences, as well as the regulation of inflammatory responses, have been ascribed. With accumulating evidence that agonism of FPR1/FPR2 can confer pro-resolution of inflammation, increased attention from academia and industry has led to the discovery of new and interesting small-molecule FPR1/FPR2 agonists. Focused attention on the development of appropriate physicochemical and pharmacokinetic profiles is yielding synthesis of new compounds with promising in vivo readouts. This review presents an overview of small-molecule FPR1/FPR2 agonist medicinal chemistry developed over the past 20 years, with a particular emphasis on interrogation in the increasingly sophisticated bioassays which have been developed.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Formil Peptídeo
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Anti-Inflamatórios
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Neutrófilos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article