Survival of P. falciparum infected red blood cell aggregates in elongational shear flow.
Lab Chip
; 24(4): 787-797, 2024 02 13.
Article
em En
| MEDLINE
| ID: mdl-38204325
ABSTRACT
Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics.
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Malária Falciparum
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article