Tumor mutation load better predicts the prognosis of patients treated with immune checkpoint inhibitors in upper gastrointestinal cancers: A systematic review and meta-analysis.
Cancer Rep (Hoboken)
; 7(2): e1959, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38204354
ABSTRACT
BACKGROUND:
Tumor mutational load (TML) has emerged as a potential biomarker for multiple solid tumors. However, data on its prognostic impact on upper gastrointestinal (UGI) cancer are limited. Therefore, the aim of this systematic review and meta-analysis was to assess the prognostic value of TML for the survival of patients with UGI cancer.METHOD:
A comprehensive search of the PubMed, Embase, Cochrane Library, and Web of Science databases was conducted up to February 13, 2023. Eleven studies met our inclusion criteria. Hazard ratios (HRs) for progression-free survival and overall survival and their 95% confidence intervals (CIs) were calculated. Subsequently, the combined HR and its 95% CI were calculated for UGI tract cancers in the high and low TML groups. I2 statistics and p-values were used to evaluate heterogeneity. Publication bias, sensitivity, and subgroup analyses were performed to determine sources of heterogeneity.RESULTS:
In total, 932 patients with UGI tract cancer from 11 publications were included. The high TML group treated with immunotherapy showed significantly improved overall survival (HR = 0.68; 95% CI 0.53, 0.86; p = .001) and progression-free survival (HR = 0.74; 95% CI 0.58, 0.95; p = .020) compared with the low TML group.CONCLUSION:
Our study demonstrated that patients with UGI tumors and higher TML have a better prognosis with immunotherapy, suggesting that TML is a promising predictive biomarker for immunotherapy. REGISTRATION The study protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO Registration No CRD42023405596).Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Checkpoint Imunológico
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Mutação
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article