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Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020.
Gebhard, Caroline E; Sütsch, Claudia; Gebert, Pimrapat; Gysi, Bianca; Bengs, Susan; Todorov, Atanas; Deforth, Manja; Buehler, Philipp K; Meisel, Alexander; Schuepbach, Reto A; Zinkernagel, Annelies S; Brugger, Silvio D; Acevedo, Claudio; Patriki, Dimitri; Wiggli, Benedikt; Beer, Jürg H; Friedl, Andrée; Twerenbold, Raphael; Kuster, Gabriela M; Pargger, Hans; Tschudin-Sutter, Sarah; Schefold, Joerg C; Spinetti, Thibaud; Henze, Chiara; Pasqualini, Mina; Sager, Dominik F; Mayrhofer, Lilian; Grieder, Mirjam; Tontsch, Janna; Franzeck, Fabian C; Wendel Garcia, Pedro D; Hofmaenner, Daniel A; Scheier, Thomas; Bartussek, Jan; Haider, Ahmed; Grämer, Muriel; Mikail, Nidaa; Rossi, Alexia; Zellweger, Núria; Opic, Petra; Portmann, Angela; von Känel, Roland; Pazhenkottil, Aju P; Messerli, Michael; Buechel, Ronny R; Kaufmann, Philipp A; Treyer, Valerie; Siegemund, Martin; Held, Ulrike; Regitz-Zagrosek, Vera.
Afiliação
  • Gebhard CE; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Sütsch C; These authors contributed equally.
  • Gebert P; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Gysi B; These authors contributed equally.
  • Bengs S; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Todorov A; Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Deforth M; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Buehler PK; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Meisel A; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Schuepbach RA; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Zinkernagel AS; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Brugger SD; Department of Biostatistics at Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Acevedo C; Institute of Intensive Care, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Patriki D; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Wiggli B; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Beer JH; Institute of Intensive Care, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Friedl A; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Twerenbold R; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Kuster GM; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Pargger H; Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
  • Tschudin-Sutter S; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
  • Schefold JC; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Spinetti T; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
  • Henze C; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
  • Pasqualini M; Department of Cardiology, University Hospital Basel, Basel, Switzerland.
  • Sager DF; Department of Cardiology and University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, Hamburg, Germany.
  • Mayrhofer L; Department of Cardiology, University Hospital Basel, Basel, Switzerland.
  • Grieder M; Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Tontsch J; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Franzeck FC; Division of Infectious Diseases and Hospital Epidemiology, University of Basel, Basel, Switzerland.
  • Wendel Garcia PD; Department of Intensive Care Medicine, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
  • Hofmaenner DA; Department of Intensive Care Medicine, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
  • Scheier T; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Bartussek J; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Haider A; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Grämer M; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Mikail N; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Rossi A; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Zellweger N; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Opic P; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Portmann A; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • von Känel R; Department of Informatics, University Hospital Basel, Basel, Switzerland.
  • Pazhenkottil AP; Institute of Intensive Care, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Messerli M; Institute of Intensive Care, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Buechel RR; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Kaufmann PA; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
  • Treyer V; Institute of Intensive Care, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Siegemund M; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, and Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States.
  • Held U; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Regitz-Zagrosek V; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Euro Surveill ; 29(2)2024 Jan.
Article em En | MEDLINE | ID: mdl-38214079
ABSTRACT
BackgroundWomen are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well as sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown.AimWe assessed the impact of sex and gender on PASC in a Swiss population.MethodOur multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients and hospitalised patients with PCR-confirmed SARS-CoV-2 infection.ResultsAmong those who remained outpatients during their first infection, women reported persisting symptoms more often than men (40.5% vs 25.5% of men; p < 0.001). This sex difference was absent in hospitalised patients. In a crude analysis, both female biological sex (RR = 1.59; 95% CI 1.41-1.79; p < 0.001) and a score summarising gendered sociocultural variables (RR = 1.05; 95% CI 1.03-1.07; p < 0.001) were significantly associated with PASC. Following multivariable adjustment, biological female sex (RR = 0.96; 95% CI 0.74-1.25; p = 0.763) was outperformed by feminine gender-related factors such as a higher stress level (RR = 1.04; 95% CI 1.01-1.06; p = 0.003), lower education (RR = 1.16; 95% CI 1.03-1.30; p = 0.011), being female and living alone (RR = 1.91; 95% CI 1.29-2.83; p = 0.001) or being male and earning the highest income in the household (RR = 0.76; 95% CI 0.60-0.97; p = 0.030).ConclusionSpecific sociocultural parameters that differ in prevalence between women and men, or imply a unique risk for women, are predictors of PASC and may explain, at least in part, the higher incidence of PASC in women. Once patients are hospitalised during acute infection, sex differences in PASC are no longer evident.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Idioma: En Ano de publicação: 2024 Tipo de documento: Article